منابع مشابه
CONTINUING MEDICAL EDUCATION HLA and skin cancer
Abstract: Skin cancer melanoma and non melanoma are common neoplasm with rising incidence over the last decades. It is an important public health problem. Its pathogenesis is not completely understood and the same happens with the genetic factors involved. The genes that encode the HLA are associated with some tumors and they may be responsible for one of the mechanisms that take part in the de...
متن کاملHLA-G in skin cancer: a wolf in sheep's clothing?
Despite well-defined and immunogenic tumor antigens, and even in the presence of tumor antigen-specific cytotoxic cells, the immune system does not appear to be very effective in eradicating cells that have undergone malignant transformation. Tumor cells, even though invading and representing a threat, are not truly "foreign" but autologous cells that have become transformed in a subtle way, en...
متن کاملSkin cancer in Yazd
Background and aim: Skin cancer is the most common human cancer. Ultraviolet radiation is now recognized as the most important risk factor for skin cancer development. Light skin colored individuals that spend more time outdoors in day are more susceptible to disease. In this study skin cancer situation in Yazd (located in a hot, dry and desert area) was reviewed.Materi...
متن کاملCorrelation of Tissue Distribution of HLA-G and HLA-E and Degree of Tumor Malignancy in Patients with Breast Cancer
Background and Aims: Human leukocyte antigen (HLA) molecules play a substantial role in T Lymphocyte-mediated adaptive immune response. Down-regulation of HLA expression may help the tumor to escape from immune surveillance. This study aimed to evaluate the correlation between HLA-G and HLA-E tissue distribution and the degree of tumor malignancy in human breast tumors. Materials and Methods:...
متن کاملBladder cancer and HLA antigens.
Genoand phenotypes in HLA antigen were compared between 86 bladder cancer patients and 95 healthy contoris. Lower frequencies of HLA-A 10 and HLA-B7 and higher frequency of H LA-B 12 were found in bladder cancer patients without statistical significance. as compared to the healthy controls. HLA-AWI9 and HLA-B40 were commonly found in two cases of bladder cancer in a family of 6 members. Since t...
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ژورنال
عنوان ژورنال: Anais Brasileiros de Dermatologia
سال: 2012
ISSN: 0365-0596
DOI: 10.1590/s0365-05962012000100001